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It’s an SNRI (serotonin-norepinephrine reuptake inhibitor) and is, for whatever reason, the type of antidepressant that works best for me. A doctor may also taper the patient off of the medication, meaning they will continuously lower the dosage until the person’s body is entirely clear of Pristiq (desvenlafaxine) My psychiatrist recommended a bit slower taper bc going from 100mg to 50mg made me feel flu aches and "eye dizziness. Here’s what Pristiq withdrawal is like. Ok, I have successfully weaned off pristiq. " The taper he gave me for going off of 100mg is: 2 weeks @ 75mg 2 weeks @50mg 2 weeks @ 25mg Then stop. I actually emailed this link to my MD because I had the same uncomfortable withdrawal symptoms each time I tried to wean off the medication. You may also benefit from additional social support as the dose is tapered A medical professional may prescribe a similar drug to Pristiq (desvenlafaxine), which will help ease the body off of the medication. I tried the every other day and had to go back on because I was so dizzy and irritable! Do not ever quit cold turkey & always consult your physician before making any changes to your meds Pristiq, also known as desvenlafaxine, is an antidepressant that I’ve taken in one form or another on and off for the past 11 years. These drugs are molecularly similar, and since Effexor is available in lower doses, it may allow for an extended taper – making the withdrawal process more tolerable Posted by Anonymous3 @anonymous3, Jan 3, 2013. There is no taper strategy for Pristiq as it only comes in 50 mg and 100 mg tablets and you cannot cut them. So getting off of Pristiq wasn’t on my short list of fun things to do. How I’m Trying to Get Off Pristiq But I seem to be successfully reducing the dose of Pristiq with minimal impact and withdrawal The withdrawal symptoms of Pristiq include dizziness, nausea, headache, irritability, insomnia, diarrhea, anxiety, fatigue, abnormal dreams, and sweating.